Arnoczky S P, Warren R F, McDevitt C A
Laboratory of Comparative Orthopaedic Research, Hospital for Special Surgery, New York, New York 10021.
Clin Orthop Relat Res. 1990 Mar(252):121-8.
The medial menisci of 14 adult dogs were replaced using a cryopreserved meniscal allograft. The morphology and metabolic activity of the transplanted allografts were then evaluated using routine histology, a vascular-injection (Spalteholz) technique, and autoroentgenography (Na2(35)SO4 incorporation) at various intervals, from two weeks to six months postoperatively. After transplantation, the allografts retained their normal gross appearance and healed to the capsular tissues of the host by fibrovascular scar tissue. Histologically, the grafts demonstrated a decrease in the number of metabolically active cells after transplantation but had a normal cellular distribution and Na2(35)SO4 uptake by three months. The allografts appeared to function normally after transplantation. Although some degenerative changes were noted in the tibial articular cartilage not covered by the meniscus, the cartilage beneath the allograft appeared normal.
使用冷冻保存的半月板同种异体移植物替换了14只成年犬的内侧半月板。然后在术后两周至六个月的不同时间间隔，使用常规组织学、血管注射（斯帕尔托霍尔茨）技术和自体X线摄影（Na2(35)SO4掺入）评估移植同种异体移植物的形态和代谢活性。移植后，同种异体移植物保持其正常的大体外观，并通过纤维血管瘢痕组织愈合至宿主的关节囊组织。组织学上，移植后移植物中代谢活跃细胞的数量减少，但到三个月时细胞分布正常且Na2(35)SO4摄取正常。移植后同种异体移植物似乎功能正常。虽然在未被半月板覆盖的胫骨关节软骨中观察到一些退行性变化，但同种异体移植物下方的软骨看起来正常。
