DeMarco D M, Santoli D, Zurier R B
Department of Medicine, University of Pennsylvania, Wistar Institute of Anatomy & Biology, Philadelphia.
J Leukoc Biol. 1994 Nov;56(5):612-5. doi: 10.1002/jlb.56.5.612.
The object of this study was to determine the effects of eicosanoid precursor fatty acids on activation and proliferation of T lymphocytes from synovial fluid and synovial tissue of rheumatoid arthritis patients. Proliferation was determined by direct cell counts; phenotypic characterization of surfaces molecules was by cytofluorometric analysis. Dihomogammalinolenic acid, arachidonic acid, and eicosapentaenoic acid suppressed proliferation of interleukin-2-dependent lymphocytes by as much as 80%; cell viability was not altered by fatty acids. Administration of particular fatty acids may prove to be a useful therapeutic intervention in rheumatoid arthritis patients because of their ability to suppress activation and proliferation of synovial compartment T lymphocytes.
本研究的目的是确定类二十烷酸前体脂肪酸对类风湿性关节炎患者滑液和滑膜组织中T淋巴细胞活化和增殖的影响。通过直接细胞计数来确定增殖情况；表面分子的表型特征通过细胞荧光分析来进行。二高-γ-亚麻酸、花生四烯酸和二十碳五烯酸可将白细胞介素-2依赖淋巴细胞的增殖抑制多达80%；脂肪酸不会改变细胞活力。特定脂肪酸的给药可能被证明是类风湿性关节炎患者一种有用的治疗干预措施，因为它们能够抑制滑膜腔T淋巴细胞的活化和增殖。
