胃肠道及其他恶性淋巴瘤患者对腺病毒E1b衍生合成肽的抗体反应及p53血清水平

Antibody response to adenovirus E1b-derived synthetic peptides and serum levels of p53 in patients with gastrointestinal and other malignant lymphomas.

作者信息

Lähdeaho M L, Lehtinen T, Aine R, Hakala T, Lehtinen M

机构信息

Department of Biomedical Sciences, University of Tampere, Finland.

出版信息

J Med Virol. 1994 Aug;43(4):393-6. doi: 10.1002/jmv.1890430413.

DOI:10.1002/jmv.1890430413

PMID:7964649

Abstract

Serum levels of p53 and antipeptide antibody levels to adenovirus type 12 (Ad12) E1b protein were measured in a case-control study of 62 newly diagnosed patients with malignant lymphoma. While patients with gastrointestinal lymphoma did not differ from their matched controls, p53 positive lymphoma patients had significantly (P < 0.04) increased antipeptide IgG antibody levels to the Ad12 E1b. Concomitant detection of serum p53 and antipeptide antibodies to Ad12 E1b was associated with an increased risk (OR = 17.0, 95% confidence limits 1.5, 58.5) of malignant lymphoma suggesting synergism between expression of Ad12 E1b and accumulation of p53 in patients with malignant lymphoma.

摘要

在一项针对62例新诊断恶性淋巴瘤患者的病例对照研究中，检测了血清中p53水平以及针对12型腺病毒（Ad12）E1b蛋白的抗肽抗体水平。胃肠道淋巴瘤患者与其匹配的对照无差异，但p53阳性的淋巴瘤患者针对Ad12 E1b的抗肽IgG抗体水平显著升高（P < 0.04）。血清p53与针对Ad12 E1b的抗肽抗体的同时检测与恶性淋巴瘤风险增加相关（比值比=17.0，95%置信区间1.5，58.5），提示在恶性淋巴瘤患者中Ad12 E1b的表达与p53的积累之间存在协同作用。