Schmidt K, Heller W, Schorer R
Anaesthesist. 1976 Jul;25(7):342-4.
Local toxic reactions from adrenaline following nerve block anaesthesia have been observed by many workers. Because of this potential danger we studied the changes of anaesthetic solutions containing adrenaline during a longer storage period. The measurements show a drop in the pH of the solutions caused by decomposition of adrenaline. This effect of storage is not detectable with the naked eye but makes analytical procedures necessary. Molecular oxygen and light decompose the solutions rapidly. After a storage period of some months the acidity of the solutions is comparable to concentrated acetic acid, a fact which could lead to local complications.
许多研究人员都观察到了神经阻滞麻醉后肾上腺素引起的局部毒性反应。由于存在这种潜在危险，我们研究了含肾上腺素的麻醉溶液在较长储存期内的变化。测量结果表明，肾上腺素分解导致溶液的pH值下降。这种储存效应肉眼无法察觉，但需要进行分析程序。分子氧和光会使溶液迅速分解。经过几个月的储存期后，溶液的酸度与浓醋酸相当，这一事实可能会导致局部并发症。
