Gibson R A, Makrides M, Neumann M A, Simmer K, Mantzioris E, James M J
Department of Peadiatrics and Child Health, Flinders Medical Centre, Bedford Park (Adelaide), Australia.
J Pediatr. 1994 Nov;125(5 Pt 2):S48-55. doi: 10.1016/s0022-3476(06)80736-5.
Commercial infant formulas with a ratio of linoleic acid (LA) to alpha-linolenic acid (ALA) of 10:1 or higher are nutritionally inadequate; the tissue levels of docosahexaenoic acid (DHA) are lower and the visual function indices are reduced in infants who are fed these formulas. All the evidence points to using LA:ALA ratios of less than 8:1, but there has been only one study in infants that used formulas with reduced LA:ALA ratios, and only biochemical indices were monitored. There is a need for both short-term studies to establish the ratios of LA to ALA that will make possible the accumulation of DHA to levels close to those in breast-fed infants and long-term trials to determine the effects of such fat blends on growth and development.
亚油酸（LA）与α-亚麻酸（ALA）比例为10:1或更高的商业婴儿配方奶粉在营养上是不充足的；食用这些配方奶粉的婴儿体内二十二碳六烯酸（DHA）的组织水平较低，视觉功能指标也会降低。所有证据都表明应使用低于8:1的LA:ALA比例，但在婴儿中仅有一项研究使用了LA:ALA比例降低的配方奶粉，且仅监测了生化指标。既需要进行短期研究以确定能使DHA积累至接近母乳喂养婴儿水平的LA与ALA比例，也需要进行长期试验以确定此类脂肪混合物对生长发育的影响。
