Milasin J, Pujić N, Dedović N, Nikolić Z, Petrović V, Dimitrijević B
J Oral Pathol Med. 1994 Aug;23(7):298-301. doi: 10.1111/j.1600-0714.1994.tb00065.x.
Nine specimens of well-differentiated squamous cell carcinoma of the lip vermilion have been analyzed for the presence of H-ras oncogene mutations, using the technique of hybridization with synthetic oligonucleotide probes on in vitro amplified tumour DNA. Five specimens harbored mutations: four in codon 12 and one in codon 13. This high incidence (55%) of mutated H-ras genes suggests that their activation may play an important role in lip tumour development and may be connected to the exposure to chemical and/or physical carcinogens.
利用合成寡核苷酸探针与体外扩增的肿瘤DNA杂交技术，对9例唇红部高分化鳞状细胞癌标本进行了H-ras癌基因突变检测。5例标本存在突变：4例为密码子12突变，1例为密码子13突变。H-ras基因如此高的突变发生率（55%）表明，其激活可能在唇部肿瘤发生过程中起重要作用，并且可能与化学和/或物理致癌物暴露有关。
