Williams H K
Department of Oral Pathology, Birmingham Dental Hospital and School, UK.
Mol Pathol. 2000 Aug;53(4):165-72. doi: 10.1136/mp.53.4.165.
Oral squamous carcinogenesis is a multistep process in which multiple genetic events occur that alter the normal functions of oncogenes and tumour suppressor genes. This can result in increased production of growth factors or numbers of cell surface receptors, enhanced intracellular messenger messenger signalling, and/or increased production of transcription factors. In combination with the loss of tumour suppressor activity, this leads to a cell phenotype capable of increased cell proliferation, with loss of cell cohesion, and the ability to infiltrate local tissue and spread to distant sites. Recent advances in the understanding of the molecular control of these various pathways will allow more accurate diagnosis and assessment of prognosis, and might lead the way for more novel approaches to treatment and prevention.
口腔鳞状细胞癌发生是一个多步骤过程，在此过程中发生多个基因事件，这些事件改变了原癌基因和肿瘤抑制基因的正常功能。这可能导致生长因子产生增加或细胞表面受体数量增多，细胞内信使信号增强，和/或转录因子产生增加。与肿瘤抑制活性丧失相结合，这导致细胞表型能够增加细胞增殖，丧失细胞黏附性，并具有浸润局部组织和扩散至远处部位的能力。对这些各种途径分子控制理解的最新进展将有助于更准确的诊断和预后评估，并可能为更新颖的治疗和预防方法开辟道路。
