Kulak Y, Arikan A, Delibalta N
University of Marmara, Faculty of Dentistry, Nişantaşi, Istanbul.
J Prosthet Dent. 1994 Sep;72(3):283-8. doi: 10.1016/0022-3913(94)90341-7.
This study compared the effects of fluconazole, fluconazole plus chlorhexidine, and placing new dentures for the treatment of generalized simple denture stomatitis. Subjects with clinical evidence of generalized simple denture stomatitis were investigated clinically and myocologically. These 45 patients were divided into three groups. The first group was given 50 mg of fluconazole in tablet form once a day for 2 weeks. The second groups were instructed to apply chlorhexidine solution to the inner surface of the denture twice a day in addition to the fluconazole treatment for 2 weeks. New dentures were made for the third group. Palatal swabs and smears were taken from each subject before, immediately after, and 2 weeks after treatment and these samples were examined myocologically. It was found that for generalized simple denture stomatitis, treatment with fluconazole in conjunction with chlorhexidine resulted in greater improvement of palatal inflammation and a decrease in candidal colonization than that with fluconazole alone or making new dentures without medication.
本研究比较了氟康唑、氟康唑加氯己定以及佩戴新假牙对治疗广泛性单纯义齿性口炎的效果。对有广泛性单纯义齿性口炎临床证据的受试者进行了临床和微生物学调查。这45名患者被分为三组。第一组每天服用一次50毫克片剂的氟康唑，持续2周。第二组除了接受2周的氟康唑治疗外，还被指示每天两次将氯己定溶液涂抹在假牙内表面。为第三组制作了新假牙。在治疗前、治疗后立即以及治疗后2周从每个受试者处采集腭拭子和涂片，并对这些样本进行微生物学检查。结果发现，对于广泛性单纯义齿性口炎，与单独使用氟康唑或不使用药物制作新假牙相比，氟康唑联合氯己定治疗可使腭部炎症得到更大改善，念珠菌定植减少。
