Garcia Amanda Aparecida Maia Neves, Sugio Carolina Yoshi Campos, de Azevedo-Silva Lucas José, Gomes Anna Clara Gurgel, Batista André Ulisses Dantas, Porto Vinicius Carvalho, Soares Simone, Neppelenbroek Karin Hermana
Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo (USP), Al. Octávio Pinheiro Brisola, 9-75, Bauru, SP, 17012-901, Brazil.
Department of Restorative Dentistry, Federal University of Paraíba, João Pessoa, PB, Brazil.
Arch Microbiol. 2021 Dec 24;204(1):75. doi: 10.1007/s00203-021-02653-4.
This systematic review aimed to evaluate the antifungal effectiveness of polymethylmetacrylate (PMMA) modified by nanoparticles (NPs) and to compare it with conventional acrylic resins for denture bases. The present study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Searches were performed using PubMed, SCOPUS, SciELO, EMBASE, and LILACS. Eligibility criteria were as recommended by PRISMA. The studies presented great variability regarding NP type, synthesis method, antifungal evaluation method, and antifungal effect. The most commonly used NPs were silver (AgNP) and zinc oxide (ZnONP), ranging in size from 10 to 100 nm. The incorporation methods were mechanical or agitated. Despite PMMA modification by ZnONP being shown in vitro to be a combination with the best antifungal effect, future studies are still needed to determine the minimum inhibitory concentration for Candida spp. and assess its biocompatibility before the protocol is clinically tested.
本系统评价旨在评估经纳米颗粒（NPs）改性的聚甲基丙烯酸甲酯（PMMA）的抗真菌效果，并将其与传统义齿基托丙烯酸树脂进行比较。本研究按照系统评价和Meta分析的首选报告项目（PRISMA）进行。使用PubMed、SCOPUS、SciELO、EMBASE和LILACS进行检索。纳入标准按照PRISMA的建议制定。这些研究在NP类型、合成方法、抗真菌评估方法和抗真菌效果方面存在很大差异。最常用的NP是银（AgNP）和氧化锌（ZnONP），尺寸范围为10至100纳米。掺入方法为机械法或搅拌法。尽管体外研究表明ZnONP对PMMA的改性具有最佳抗真菌效果组合，但在该方案进行临床测试之前，仍需要进一步研究以确定念珠菌属的最低抑菌浓度并评估其生物相容性。
