Arikan A, Kulak Y, Kadir T
Department of Prosthetic Dentistry, Marmara University, Istanbul, Turkey.
J Oral Rehabil. 1995 May;22(5):365-9. doi: 10.1111/j.1365-2842.1995.tb00786.x.
The purpose of this study was to compare the treatment effects of fluconazole, fluconazole plus chlorhexidine and the fitting of new dentures upon the treatment of denture stomatitis and 15 subjects with clinical evidence of localized simple denture stomatitis were investigated clinically and mycologically. Patients with clinical evidence of generalized simple denture stomatitis were divided into three treatment groups. The first group was given 50 mg of fluconazole tablets daily for 2 weeks. The second group were instructed to apply chlorhexidine solution to the inner surface of the denture twice a day in addition to fluconazole treatment for 2 weeks. New dentures were constructed for the third group. Patients with clinical evidence of localized simple denture stomatitis were fitted new dentures without antifungal therapy. Palatal swabs were taken from each subject before, immediately after, and 2 weeks after the end of treatment, and the samples were examined mycologically in order to identify yeast colonies. It was found that for generalized simple denture stomatitis, treatment with fluconazole plus chlorhexidine resulted in better improvement of palatal inflammation than that by either fluconazole or the fitting of new dentures without medication. Whereas fitting new dentures did not reduce inflammation in patients with generalized simple denture stomatitis, the beneficial effects of prosthetic treatment were seen in patients with localized simple denture stomatitis.
本研究的目的是比较氟康唑、氟康唑加氯己定以及佩戴新假牙对义齿性口炎的治疗效果，并对15例有局限性单纯义齿性口炎临床证据的受试者进行了临床和真菌学调查。有广泛性单纯义齿性口炎临床证据的患者被分为三个治疗组。第一组每天服用50毫克氟康唑片，持续2周。第二组除接受氟康唑治疗2周外，还被指示每天两次将氯己定溶液涂于假牙内表面。为第三组制作新假牙。有局限性单纯义齿性口炎临床证据的患者佩戴新假牙，不进行抗真菌治疗。在治疗前、治疗结束后即刻以及治疗结束后2周从每个受试者采集腭部拭子，并对样本进行真菌学检查以鉴定酵母菌落。结果发现，对于广泛性单纯义齿性口炎，氟康唑加氯己定治疗导致腭部炎症的改善比单独使用氟康唑或不使用药物佩戴新假牙更好。虽然佩戴新假牙并未减轻广泛性单纯义齿性口炎患者的炎症，但在局限性单纯义齿性口炎患者中观察到了修复治疗的有益效果。
