Alper K R, Lotsof H S, Frenken G M, Luciano D J, Bastiaans J
Department of Psychiatry, New York University School of Medicine, NY 10016, USA.
Am J Addict. 1999 Summer;8(3):234-42. doi: 10.1080/105504999305848.
Ibogaine is an alkaloid with putative effect in acute opioid withdrawal. Thirty-three cases of treatments for the indication of opioid detoxification performed in non-medical settings under open label conditions are summarized involving an average daily use of heroin of .64 +/- .50 grams, primarily by the intravenous route. Resolution of the signs of opioid withdrawal without further drug seeking behavior was observed within 24 hours in 25 patients and was sustained throughout the 72-hour period of posttreatment observation. Other outcomes included drug seeking behavior without withdrawal signs (4 patients), drug abstinence with attenuated withdrawal signs (2 patients), drug seeking behavior with continued withdrawal signs (1 patient), and one fatality possibly involving surreptitious heroin use. The reported effectiveness of ibogaine in this series suggests the need for systematic investigation in a conventional clinical research setting.
伊波加因是一种生物碱，据推测对急性阿片类药物戒断有作用。总结了33例在开放标签条件下于非医疗环境中进行的阿片类药物解毒治疗病例，这些患者主要通过静脉途径平均每日使用0.64±0.50克海洛因。25例患者在24小时内出现阿片类药物戒断症状消失且无进一步觅药行为，并在治疗后72小时的观察期内持续保持。其他结果包括有觅药行为但无戒断症状（4例患者）、戒毒但戒断症状减轻（2例患者）、有觅药行为且戒断症状持续（1例患者），以及1例可能涉及秘密使用海洛因的死亡病例。该系列中报道的伊波加因有效性表明需要在传统临床研究环境中进行系统研究。
