Cardamakis E, Kotoulas I G, Metalinos K, Mantouvalos H, Relakis K, Scarpari M, Korantzis A, Papathanasiou Z
Department of Cytology, General Hospital of Athens, Greece.
J Urol. 1994 Dec;152(6 Pt 1):2011-3. doi: 10.1016/s0022-5347(17)32293-0.
The effectiveness of intraurethral 5-fluorouracil and systemic administration of interferon-alpha 2a in the therapy of condylomata acuminata or flat condylomata of the urethra is assessed. From March 1986 to September 1991, 1,372 male sexual partners of women with condylomata acuminata, flat condylomata or cervical intraepithelial neoplasia underwent urethroscopy and brush cytological examination of the urethra. Of these men 305 (22.23%) had intraepithelial human papillomavirus (confirmed cytologically) and 284 were treated. The best treatment modalities, regardless of the type of lesion, were the combinations of 5-fluorouracil plus high (95.34%) and low (70.58%) dose interferon-alpha 2a. Interferon-alpha 2a can be used as first line treatment with 5-fluorouracil cream in patients with intraurethral condylomata acuminata or flat condylomata.
评估尿道内注射5-氟尿嘧啶与全身应用α-2a干扰素治疗尖锐湿疣或尿道扁平湿疣的疗效。1986年3月至1991年9月，1372名患有尖锐湿疣、扁平湿疣或宫颈上皮内瘤变的女性的男性性伴侣接受了尿道镜检查及尿道刷细胞学检查。这些男性中，305例（22.23%）存在上皮内人乳头瘤病毒（经细胞学确诊），其中284例接受了治疗。无论病变类型如何，最佳治疗方式为5-氟尿嘧啶联合高剂量（95.34%）和低剂量（70.58%）α-2a干扰素。对于尿道内尖锐湿疣或扁平湿疣患者，α-2a干扰素可与5-氟尿嘧啶乳膏联合用作一线治疗。
