Relakis K, Cardamakis E, Korantzis A, Metalinos K, Mantouvalos H, Papathanasiou Z, Michopoulos J, Stathopoulos E, Kotoulas I G, Tzingounis V
Euromedica Medical Center, Athens, Greece.
Eur J Gynaecol Oncol. 1996;17(6):529-33.
This study was undertaken to assess the effect of CO2 laser vaporization, 5-fluorouracil 5% (5-FU) topical application and Interferon alpha-2a (IFA alpha-2a) in the treatment of C.A. or F.C. of the male genital tract. From March 1986 to September 1991, 1372 men, sexual partners of women with F.C. or C.A. or cervical intraepithelial neoplasia, were submitted to peoscopy. One thousand and nineteen (74.27%) men presented with various penile lesions caused by HPV (histologically confirmed); of these 505 were treated for C.A. or F.C. or a combination of F.C. and C.A. The best treatment modalities, irrespective of the kind of lesion, were found to be the combination of 5-FU plus IFN alpha-2a (high dose) (98.27%), the combination of CO2 laser vaporization plus 5-FU plus IFN alpha-2a (high dose) (93.93%) and the combination of CO2 laser vaporization plus 5-FU (87.23%). In conclusion we believe that IFN alpha-2a can be used with excellent results as first line treatment in combination with CO2 laser vaporization or/plus 5-FU in patients with C.A. or F.C. or combined condylomata.
本研究旨在评估二氧化碳激光汽化、5% 5-氟尿嘧啶（5-FU）局部应用以及干扰素α-2a（IFAα-2a）治疗男性生殖道尖锐湿疣（C.A.）或扁平湿疣（F.C.）的效果。1986年3月至1991年9月，1372名患有扁平湿疣或尖锐湿疣或宫颈上皮内瘤变女性的男性性伴侣接受了窥镜检查。1019名（74.27%）男性出现由人乳头瘤病毒引起的各种阴茎病变（经组织学证实）；其中505例接受了尖锐湿疣或扁平湿疣或两者合并的治疗。无论病变类型如何，发现最佳治疗方式为5-FU加IFNα-2a（高剂量）联合应用（98.27%）、二氧化碳激光汽化加5-FU加IFNα-2a（高剂量）联合应用（93.93%）以及二氧化碳激光汽化加5-FU联合应用（87.23%）。总之，我们认为，对于患有尖锐湿疣或扁平湿疣或合并湿疣的患者，IFNα-2a作为一线治疗药物，与二氧化碳激光汽化或/加5-FU联合使用时可取得优异疗效。
