Cornel E B, Oosterwijk E, van de Streek J D, Grutters G, Debruyne F M, Schalken J A, Oosterhof G O
Department of Urology, University Hospital, Nijmegen, The Netherlands.
J Urol. 1994 Dec;152(6 Pt 1):2164-6. doi: 10.1016/s0022-5347(17)32344-3.
The influence of high energy shock waves (HESW) on the local concentration of systemically given TNF-alpha was studied in a syngeneic rat bladder tumor model. 125I-TNF-alpha was injected intravenously and within 1 minute was followed by HESW tumor exposure. High energy shock waves were generated using an experimental shock wave emitter based on the Siemens Lithostar Plus. Administration of HESW to RBT323 tumors resulted in a 3-fold increase in uptake of 125I-TNF-alpha in the tumor compared with nontreated tumors, whereas the tissue distribution and pharmacokinetics of nontumor tissue were similar irrespective of HESW exposure. These results demonstrate that HESW administration leads to an increase in the local concentration of a systemically given drug. The capacity of HESW to increase local drug concentrations will be of importance in designing more effective combined treatment strategies.
在同基因大鼠膀胱肿瘤模型中，研究了高能冲击波（HESW）对全身给予的肿瘤坏死因子-α（TNF-α）局部浓度的影响。静脉注射125I-TNF-α，1分钟内对肿瘤进行高能冲击波照射。使用基于西门子Lithostar Plus的实验性冲击波发射器产生高能冲击波。对RBT323肿瘤给予高能冲击波后，与未处理的肿瘤相比，肿瘤对125I-TNF-α的摄取增加了3倍，而无论是否暴露于高能冲击波，非肿瘤组织的组织分布和药代动力学相似。这些结果表明，给予高能冲击波可导致全身给予药物的局部浓度增加。高能冲击波增加局部药物浓度的能力在设计更有效的联合治疗策略中将具有重要意义。
