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定量计算机断层扫描在骨质疏松症及其相关疾病中的临床应用

[The clinical application of quantitative computed tomography to osteoporosis and it's related disorders].

作者信息

Narushima M, Yagi H, Konishi H, Matsuda M, Ota K

机构信息

Department of Orthopaedic Surgery, Fuchu Hospital.

出版信息

Nihon Rinsho. 1994 Sep;52(9):2335-43.

PMID:7967078
Abstract

Bone mineral in spinal vertebral bone, using the methods of single and dual energy tomographies (SEQCT and DEQCT) were applied to the studies of osteoporosis. The measurement of bone mineral in spinal bone with DEQCT was useful for elimination of fat mass effect in bone marrow, but has poorer reprocibility and higher dose-expose of radioactivity, compared with these of bone mineral by the SEQCT method. Bone mineral in the third lumbar spine of osteoporosis patients without bone fracture was employed in the SEQCT method, indicated that bone loss was age dependent in both sex and bone mineral showed O level which might be influenced by the fat mass in the marrow. The fat mass in the marrow was age-dependent. Bone mineral, in addition to fat mass effect was evaluated to give a diagnosis of osteoporosis. Physical activity was responsible for an increase of bone mineral. The more disable physical activity life was, the more diminished bone mineral was. The role of bone mineral was rationally distributed, and unbalanced bone mineral disposition permitted to induction into the degenerative central nervous system. The measurement of bone mineral in the spinal bone by the SEQCT method made possible a diagnosis and prevention of osteoporosis and observation of the therapeutic effect and clinical course was possible in osteoporosis patients.

摘要

利用单能和双能断层扫描法(SEQCT和DEQCT)对脊柱椎骨中的骨矿物质进行了骨质疏松症研究。与SEQCT法测量骨矿物质相比,DEQCT测量脊柱骨中的骨矿物质有助于消除骨髓中脂肪量的影响,但再现性较差且放射性剂量暴露较高。对无骨折的骨质疏松症患者第三腰椎的骨矿物质采用SEQCT法,结果表明骨丢失在两性中均与年龄有关,且骨矿物质显示为O水平,这可能受骨髓中脂肪量的影响。骨髓中的脂肪量与年龄有关。除脂肪量影响外,还对骨矿物质进行评估以诊断骨质疏松症。体力活动会导致骨矿物质增加。体力活动能力越差,骨矿物质减少得越多。骨矿物质的作用分布合理,骨矿物质分布不平衡会导致退行性中枢神经系统疾病。通过SEQCT法测量脊柱骨中的骨矿物质使得骨质疏松症的诊断和预防成为可能,并且在骨质疏松症患者中观察治疗效果和临床病程也是可行的。

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