Beik Ahmad, Joukar Siyavash, Najafipour Hamid
Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
J Tradit Complement Med. 2020 Apr 6;10(3):275-287. doi: 10.1016/j.jtcme.2020.03.002. eCollection 2020 May.
This paper aimed to compile information on plants or their compounds which have experimentally shown antiarrhythmic effect and to scrutinize the efficacy and potency of them and their potential interaction with conventional cardiac drugs. Literature searches were accomplished by using numerous electronic databases, and the available knowledge on different parts of herbs and their ingredients with antiarrhythmic effects up to 2019 were identified and collected. The results indicate that 36 herbs or their derivatives can be effective in the treatment of arrhythmias, especially in animal and cellular models. They affect various ionic channels in different action potential phases. The alterations in ionic currents lead to changing in the amplitude and duration of the action potential, effective refractory period, maximum velocity, resting membrane potential, channel trafficking, or intracellular calcium concentration. The agents that prolong action potential duration and effective refractory period such as dauricine and sophocarpine seem to be more beneficial if more comprehensive studies confirm their efficacy and safety. It is noteworthy that the consumption of some herbal agents for cardiovascular (e.g. Hawthorn and Ginseng) or other (e.g. Ginseng and Licorice) therapeutic purposes may boost the pro-arrhythmogenic effect of current cardiovascular drugs such as cardiac glycosides. This study accentuates known plants or their derivatives with anti-arrhythmic effects, potential interaction with other cardiac drugs, and the possible mechanisms involved. It can assist clinicians and scientists in research and therapeutic approaches to the management of cardiac arrhythmias.
本文旨在汇总关于已通过实验证明具有抗心律失常作用的植物或其化合物的信息，并详细审查它们的功效和效力以及它们与传统心脏药物的潜在相互作用。通过使用众多电子数据库完成文献检索，确定并收集了截至2019年关于草药不同部位及其具有抗心律失常作用的成分的现有知识。结果表明，36种草药或其衍生物可有效治疗心律失常，尤其是在动物和细胞模型中。它们在不同的动作电位阶段影响各种离子通道。离子电流的改变导致动作电位的幅度和持续时间、有效不应期、最大速度、静息膜电位、通道运输或细胞内钙浓度发生变化。如果更全面的研究证实其疗效和安全性，那么延长动作电位持续时间和有效不应期的药物，如蝙蝠葛碱和槐果碱，似乎更有益。值得注意的是，为了心血管（如山楂和人参）或其他（如人参和甘草）治疗目的而服用某些草药制剂，可能会增强当前心血管药物（如强心苷）的促心律失常作用。本研究强调了已知的具有抗心律失常作用的植物或其衍生物、与其他心脏药物的潜在相互作用以及所涉及的可能机制。它可以帮助临床医生和科学家在研究和治疗方法上管理心律失常。
