Kuechle M K, Hutton K P, Muller S A
Department of Dermatology, Mayo Clinic Rochester, MN 55905.
Mayo Clin Proc. 1994 Dec;69(12):1166-71. doi: 10.1016/s0025-6196(12)65770-x.
To identify patients examined in the Mayo Clinic Department of Dermatology whose pemphigus was attributable to an angiotensin-converting enzyme inhibitor and to compare these cases with previously reported cases of drug-induced pemphigus.
A retrospective review of medical records revealed two cases of captopril-induced pemphigus and one of enalapril-induced pemphigus. Our patients had substantially increased circulating IgG autoantibodies to intercellular substance, as detected on monkey esophagus substrate.
Our findings contrast those of other reports of drug-induced pemphigus in which circulating autoantibodies are implied to be low or absent.
确定在梅奥诊所皮肤科接受检查的天疱疮患者，其天疱疮由血管紧张素转换酶抑制剂引起，并将这些病例与先前报道的药物性天疱疮病例进行比较。
对病历的回顾性研究发现两例卡托普利诱发的天疱疮和一例依那普利诱发的天疱疮。在猴食管底物上检测发现，我们的患者循环中针对细胞间物质的IgG自身抗体大幅增加。
我们的发现与其他药物性天疱疮报告相反，其他报告暗示循环自身抗体水平较低或不存在。
