Pharmacology Unit, Department of Science of Health, Magna Graecia University, Catanzaro, Italy.
Dermatology Unit, Department of Science of Health, Magna Graecia University, Catanzaro, Italy.
Dermatol Ther. 2019 Jan;32(1):e12748. doi: 10.1111/dth.12748. Epub 2018 Oct 11.
Pemphigus is a group of autoimmune diseases characterized by the formation of erosions and/or flaccid bullae of the skin and/or mucosae. The definition "drug-induced pemphigus" has been coined to indicate cases of pemphigus with clinical, histological and immunopathologic features similar to those of the idiopathic disease but induced by systemic ingestion or local use of some drugs. The present authors analyzed a case series of three case reports with clinical and pharmacological features compatible with the diagnosis of angiotensin converting enzyme inhibitors or angiotensin II receptor blocker drug-induced pemphigus. The patients were visited by the dermatological Unit of Magna Graecia University in Catanzaro. All suspected drug induced pemphigus were treated by suspending the suspected drug and by starting a treatment with systemic corticosteroid drugs, leading to a remission of the clinical manifestations in some months. When a drug induced bullous disease is probable, it is necessary to interrupt the suspected substance and to start a high dose treatment with corticosteroid drugs to resolve the clinical case in a short period of time.
天疱疮是一组自身免疫性疾病，其特征为皮肤和/或黏膜出现糜烂和/或松弛性水疱。“药物诱导性天疱疮”的定义是指具有与特发性疾病相似的临床、组织学和免疫病理学特征的天疱疮病例，但由系统性摄入或局部使用某些药物引起。本文作者分析了三例病例报告的病例系列，这些病例具有与血管紧张素转换酶抑制剂或血管紧张素 II 受体阻滞剂药物诱导性天疱疮相符的临床和药理学特征。这些患者在卡坦扎罗的 Magna Graecia 大学皮肤科就诊。所有疑似药物诱导性天疱疮均通过停用可疑药物并开始全身性皮质类固醇药物治疗来治疗，在几个月内使临床表现得到缓解。当疑似药物诱导性大疱性疾病时，有必要中断可疑物质，并开始大剂量皮质类固醇药物治疗，以在短时间内解决临床病例。
