Fischer J L
Pathol Biol (Paris). 1976 Nov;24(9):619-22.
Low dose X irradiations centred on one or two aortic and branchial arches of 3-day check embryos result in teratogenic effects on the arteries (21-92%) and in low mortality (4-12%). Histological studies of abnormal arteries show different structural malformations of the arterial wall: inorganized arterial fibres, abnormal intima, newly formed arterial tissue in arterial lumen, coalescence of two arteries. It is suggested that a disturbance at the aortic differentiation level results under our experimental conditions in the observed arterial abnormalities.
对3日龄检查胚胎的一个或两个主动脉弓和鳃弓进行低剂量X射线照射，会对动脉产生致畸作用（21%-92%），且死亡率较低（4%-12%）。对异常动脉的组织学研究显示，动脉壁存在不同的结构畸形：动脉纤维紊乱、内膜异常、动脉腔内新形成的动脉组织、两条动脉融合。有人认为，在我们的实验条件下，主动脉分化水平的紊乱导致了观察到的动脉异常。
