Fischer J L
Arch Anat Histol Embryol. 1977;60:147-62.
X-irradiation of branchial and aortic arches of 3 day old chick embryos is lethal in only a small number of cases (3-12,5%), but results in a high proportion (30-96%) of arterial malformations. The production of arterial anomalies is not random, but is related to the experimental method used and the function of the aortic arch with respect to the dynamics of circulation. Numerical and statistical studes, together with histological examination of the irradiated branchial and aortic arches, have revealed the importance of: the immediate environment of the aortic arch on its morphogenesis, the moment at which the teratogenic aggression occurs and the role of haemodynamics in the fate of the aortic arches. To explain aortic teratogenesis, we propose a hypothesis according to which all arterial anomalies are of morphogenetic origin. These anomalies can result in circulatory modifications which, in turn, cause new malformations.
对3日龄鸡胚的鳃弓和主动脉弓进行X射线照射，仅在少数情况下（3% - 12.5%）是致命的，但会导致高比例（30% - 96%）的动脉畸形。动脉异常的产生并非随机，而是与所使用的实验方法以及主动脉弓在循环动力学方面的功能有关。数值和统计研究，以及对受照射的鳃弓和主动脉弓的组织学检查，揭示了以下因素的重要性：主动脉弓的直接环境对其形态发生的影响、致畸侵袭发生的时刻以及血流动力学在主动脉弓命运中的作用。为了解释主动脉致畸作用，我们提出一个假说，即所有动脉异常均起源于形态发生。这些异常可导致循环改变，进而引起新的畸形。
