Larsson L H, Carlsson-Nordlander B, Svanborg E
Department of Oto-rhino-laryngology, Karolinska Institute at Söder Hospital, Stockholm, Sweden.
Laryngoscope. 1994 Nov;104(11 Pt 1):1362-8. doi: 10.1288/00005537-199411000-00008.
Fifty unselected consecutive patients with obstructive sleep apnea syndrome (OSAS) diagnosed by nocturnal recordings of respiration movements by a static charge sensitive bed (SCSB) and oximetry, alone or combined with polysomnography, were studied. Renewed SCSB-oximetry recordings evaluated treatment. Six months after surgery, 30 of 50 were classified as responders. Twenty-one months after surgery, 19 of 49 were responders. Patients who relapsed showed a significant increase in mean body mass index (BMI). Four years after surgery, 24 of 48 patients were responders. Preoperative BMI was significantly lower in the responder group. Subsequent treatment was required in 15 nonresponders. There was no correlation between patients' subjective improvement and objective results. The study resulted in the following conclusions: 1. The responder rate to UPPP in unselected patients is low. 2. Obesity and high indices of nocturnal respiratory disturbance are negative predictors. 3. The patients' subjective recovery alone must not be used for postoperative evaluation. 4. With regular follow-up and the use of the treatment alternatives available today, the majority of OSAS patients can receive effective treatment.
对50例未经挑选的连续性阻塞性睡眠呼吸暂停综合征（OSAS）患者进行了研究，这些患者通过静态电荷敏感床（SCSB）和血氧测定法进行夜间呼吸运动记录，单独或联合多导睡眠图进行诊断。重新进行SCSB - 血氧测定记录以评估治疗效果。术后6个月，50例中有30例被归类为反应者。术后21个月，49例中有19例为反应者。复发的患者平均体重指数（BMI）显著增加。术后4年，48例患者中有24例为反应者。反应者组术前BMI显著较低。15例无反应者需要后续治疗。患者的主观改善与客观结果之间无相关性。该研究得出以下结论：1. 未经挑选的患者对悬雍垂腭咽成形术（UPPP）的反应率较低。2. 肥胖和夜间呼吸紊乱高指数是负面预测因素。3. 术后评估不能仅依据患者的主观恢复情况。4. 通过定期随访并使用当今可用的治疗替代方法，大多数OSAS患者可获得有效治疗。
