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悬雍垂腭咽成形术治疗阻塞性睡眠呼吸暂停综合征的长期随访。术后6个月和2年的睡眠呼吸暂停记录结果及主观评估

Long-time follow-up after UPPP for obstructive sleep apnea syndrome. Results of sleep apnea recordings and subjective evaluation 6 months and 2 years after surgery.

作者信息

Larsson H, Carlsson-Nordlander B, Svanborg E

机构信息

Department of Otorhinolaryngology, Karolinska Institute, Södersjukhuset, Stockholm, Sweden.

出版信息

Acta Otolaryngol. 1991;111(3):582-90. doi: 10.3109/00016489109138387.

DOI:10.3109/00016489109138387
PMID:1887784
Abstract

Fifty unselected consecutive patients with obstructive sleep apnea syndrome (OSAS) underwent uvulopalatopharyngoplasty (UPPP). The diagnosis was based on the patient's history and recording of respiration movements (Static Charge Sensitive Bed. SCSB) and oximetry, alone or combined with polysomnography. Renewed SCSB oximetry recordings were used to evaluate the success of the treatment. Six months postoperatively 40% of the patients were classified as non-responders, i.e. their oxygen desaturation indices (ODI) were reduced by less than 50% or were still above 20. The mean body mass index (BMI) was significantly higher in the non-responder group. A second recording with complete data was obtained in 45 patients after an average of 21 months. It was found that 9 patients who had been responders in the first postoperative recording had become non-responders. Only 18 of the patients with complete data could be verified as responders after 2 years. The patients who relapsed showed a significant increase in mean BMI between the first and second postoperative recordings compared to the patients who remained responders. There were no significant differences between responders and non-responders concerning age or preoperative severity of OSAS expressed as ODI, nadir SaO2 and percentage of obstructive periodic breathing. Of the non-responders, 47% in the first postoperative recording and 52% in the second reported complete recovery from excessive daytime sleepiness. This subjective improvement was not correlated to the objective results. The conclusions of this study are thus that one postoperative recording is not enough to estimate the outcome of UPPP and that statements of the patient's subjective recovery alone must not be used for this purpose.

摘要

五十例未经挑选的连续性阻塞性睡眠呼吸暂停综合征(OSAS)患者接受了悬雍垂腭咽成形术(UPPP)。诊断依据患者病史、呼吸运动记录(静态电荷敏感床,SCSB)和血氧饱和度测定,单独或结合多导睡眠图进行。采用更新后的SCSB血氧饱和度测定记录评估治疗效果。术后六个月,40%的患者被归类为无反应者,即他们的氧去饱和指数(ODI)降低不到50%或仍高于20。无反应者组的平均体重指数(BMI)显著更高。平均21个月后,45例患者获得了完整数据的第二次记录。结果发现,在术后第一次记录时为有反应者的9例患者变成了无反应者。两年后,只有18例有完整数据的患者被证实为有反应者。与仍为有反应者的患者相比,复发患者在术后第一次和第二次记录之间的平均BMI显著增加。在年龄或术前以ODI、最低血氧饱和度(SaO2)和阻塞性周期性呼吸百分比表示的OSAS严重程度方面,有反应者和无反应者之间没有显著差异。在无反应者中,术后第一次记录时有47%、第二次记录时有52%报告白天过度嗜睡完全恢复。这种主观改善与客观结果无关。因此,本研究的结论是,一次术后记录不足以评估UPPP的结果,且不能仅以患者的主观恢复情况来判断。

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