Cho C H
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Life Sci. 1994;55(20):1521-35. doi: 10.1016/0024-3205(94)00313-0.
The pathogenetic mechanisms of different types of peptic ulcer are still unclear. Extensive investigations have been focused on the identification of potential endogenous ulcerogenic mediators in animals and men. These studies are important in the development of a better therapeutic agent, either to prevent or to cure peptic ulcer in humans. Several endogenous substances have been identified and are reported to be involved in the production of gastrointestinal lesions in animals. Also these substances were increased during inflammatory responses and their actions were reported as vascular dependent and possibly free radicals related. Reports related to the types of these mediators have been extensive. The more important ones include some of the lipid metabolites, neuropeptides, biogenic amines, and also Helicobacter pylori and reactive free radicals. The present study summarizes the ulcerogenic mechanisms of these substances and the types of ulcer involved. More current information may enable us to understand better the etiology of peptic ulcer and possibly its prevention and cure in man. Any particular types of ulceration will not be specifically discussed in this article, because they have been extensively studied and reviewed.
不同类型消化性溃疡的发病机制仍不明确。广泛的研究集中于在动物和人体中识别潜在的内源性致溃疡介质。这些研究对于开发更好的治疗药物很重要，无论是预防还是治愈人类消化性溃疡。已识别出几种内源性物质，据报道它们与动物胃肠道病变的产生有关。这些物质在炎症反应期间也会增加，并且据报道它们的作用与血管相关且可能与自由基有关。有关这些介质类型的报告很多。更重要的包括一些脂质代谢产物、神经肽、生物胺，还有幽门螺杆菌和活性自由基。本研究总结了这些物质的致溃疡机制以及所涉及的溃疡类型。更多的最新信息可能使我们更好地理解消化性溃疡的病因以及可能的预防和治疗方法。本文不会具体讨论任何特定类型的溃疡，因为它们已被广泛研究和综述。
