The role of endogenous ulcerogenic mediators in the pathogenesis of peptic ulcer.

The pathogenetic mechanisms of different types of peptic ulcer are still unclear. Extensive investigations have been focused on the identification of potential endogenous ulcerogenic mediators in animals and men. These studies are important in the development of a better therapeutic agent, either to prevent or to cure peptic ulcer in humans. Several endogenous substances have been identified and are reported to be involved in the production of gastrointestinal lesions in animals. Also these substances were increased during inflammatory responses and their actions were reported as vascular dependent and possibly free radicals related. Reports related to the types of these mediators have been extensive. The more important ones include some of the lipid metabolites, neuropeptides, biogenic amines, and also Helicobacter pylori and reactive free radicals. The present study summarizes the ulcerogenic mechanisms of these substances and the types of ulcer involved. More current information may enable us to understand better the etiology of peptic ulcer and possibly its prevention and cure in man. Any particular types of ulceration will not be specifically discussed in this article, because they have been extensively studied and reviewed.