Hirohashi S, Uchida H, Yoshikawa K, Fujita N, Ohtomo K, Yuasa Y, Kawamura Y, Matsui O
Department of Radiology, Nara Medical University, Japan.
Magn Reson Imaging. 1994;12(6):837-46. doi: 10.1016/0730-725x(94)92024-9.
Clear identification of bowel has been thought to be essential in diagnosis by abdominal MRI. We have completed the clinical phase III trial of a new oral contrast agent (FerriSeltz) which is a ferric ammonium citrate based bowel contrast agent. FerriSeltz is a powder that is dissolved in 300 ml water to create a grape-flavored effervescent drink. We have evaluated the usefulness of FerriSeltz, and compared groups receiving 600 mg and 1200 mg of ferric ammonium citrate, the use and nonuse of parasympathetic blockers, and patients with and without fasting in 174 patients who underwent abdominal MRI using this agent. FerriSeltz was found to brighten the stomach and duodenum, contribute to the improvement in diagnostic efficacy, be safe as a bowel contrast agent in abdominal MRI, and be associated with an extremely low incidence of side effects (only mild diarrhea in one of 169 patients). No significant differences were found in the contribution to the improvement in diagnostic efficacy between the two dosage groups, the use and nonuse of parasympathetic blockers, or patients with and without fasting. We concluded that ferric ammonium citrate based compound (FerriSeltz) is a promising bowel contrast agent in abdominal MRI.
通过腹部MRI进行诊断时，清晰识别肠道被认为至关重要。我们已完成一种新型口服造影剂（FerriSeltz）的III期临床试验，该造影剂是以柠檬酸铁铵为基础的肠道造影剂。FerriSeltz是一种粉末，可溶于300毫升水中制成葡萄味泡腾饮料。我们评估了FerriSeltz的效用，并在174例使用该造影剂进行腹部MRI检查的患者中，比较了接受600毫克和1200毫克柠檬酸铁铵的组、使用和未使用副交感神经阻滞剂的组以及禁食和未禁食的患者。结果发现，FerriSeltz可使胃和十二指肠显影更清晰，有助于提高诊断效能，作为腹部MRI的肠道造影剂是安全的，且副作用发生率极低（169例患者中仅1例出现轻度腹泻）。在两个剂量组、使用和未使用副交感神经阻滞剂的组或禁食和未禁食的患者之间，对提高诊断效能的贡献未发现显著差异。我们得出结论，基于柠檬酸铁铵的化合物（FerriSeltz）是腹部MRI中一种很有前景的肠道造影剂。
