Zaragoza M R, Ritchey M L, Walter A
Department of Surgery, University of Michigan, Ann Arbor.
Med Pediatr Oncol. 1995 Jan;24(1):61-2. doi: 10.1002/mpo.2950240114.
Inadvertent intrathecal administration of vincristine results in severe neurotoxicity. Motor and sensory bladder dysfunction have been reported but the long-term urologic consequences are unknown due to the associated high mortality. We report a case of accidental intrathecal vincristine administration with patient survival and follow-up of 24 months. The child developed a lower motor neuron neuropathic bladder requiring intermittent self-catheterization of the bladder. Urinary tract management of these children should be based on the urodynamic findings.
误将长春新碱鞘内注射会导致严重的神经毒性。已有运动和感觉性膀胱功能障碍的报道,但由于相关的高死亡率,长期的泌尿系统后果尚不清楚。我们报告一例意外鞘内注射长春新碱的病例,患者存活并随访了24个月。该患儿出现了下运动神经元神经性膀胱,需要间歇性自行导尿。这些患儿的尿路管理应基于尿动力学检查结果。