Beghi E, Monticelli M L, Sessa A, Simone P
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Mov Disord. 1994 Jul;9(4):403-8. doi: 10.1002/mds.870090405.
The prevalence and characteristics of parkinsonism have been assessed in two separate geographic areas in Italy (Arcisate and San Giovanni Rotondo). A total of 28,377 patients of 23 general practitioners (GPs) were the reference population. Fifty-eight patients were traced by the GP as having typical parkinsonian features or being treated with antiparkinson drugs. Among 53 subjects, 21 of them untreated, parkinsonism was subsequently confirmed neurologically. The overall crude prevalence rate was 1.87 cases per 1,000 (Arcisate 1.81; San Giovanni Rotondo 2.01). The age- and sex-adjusted prevalence rates were 1.84 in Arcisate and 2.04 in San Giovanni Rotondo. After exclusion of drug-related parkinsonism, the rates were 1.48 and 1.90, respectively. Even with some inconsistencies within the two study areas, the prevalence tended to be higher in San Giovanni Rotondo, to prevail in women, and to increase significantly with age. Presumed etiological factors for parkinsonism were recorded in 34% of the cases (mostly drugs). In two thirds of the cases the disease ran a mild course. The present study shows that the GP proves a valuable reference for surveys of parkinsonism in Italy.
帕金森症的患病率及特征在意大利的两个不同地理区域（阿尔奇萨特和圣乔瓦尼-罗通多）进行了评估。23名全科医生（GP）的总共28377名患者作为参考人群。有58名患者被全科医生查出有典型的帕金森症特征或正在接受抗帕金森药物治疗。在这53名受试者中，21名未接受治疗，随后经神经学检查确诊为帕金森症。总体粗患病率为每1000人中有1.87例（阿尔奇萨特为1.81；圣乔瓦尼-罗通多为2.01）。年龄和性别调整后的患病率在阿尔奇萨特为1.84，在圣乔瓦尼-罗通多为2.04。排除药物性帕金森症后，患病率分别为1.48和1.90。即使两个研究区域存在一些不一致之处，但圣乔瓦尼-罗通多的患病率往往更高，女性更为常见，且随年龄显著增加。34%的病例记录了帕金森症的推测病因（主要是药物）。三分之二的病例病情发展较为轻微。本研究表明，全科医生在意大利帕金森症调查中是一个有价值的参考对象。
