Franek E, Kokot F, Wiecek A, Pawłowski W, Myrta J, Szewczyk W, Bar A
Department of Nephrology, Silesian School of Medicine, Katowice, Poland.
Nephron. 1994;67(4):431-5. doi: 10.1159/000188017.
High erythropoietin (EPO) levels in cyst fluid and blood plasma in patients with autosomal dominant polycystic kidney disease (ADPKD) have been reported. In the present study we assessed EPO levels and the biochemical composition of cyst fluid obtained from 50 simple renal cysts. Basing on cyst fluid/plasma sodium ratio 38 cysts were classified as cysts of proximal origin, and 12 as cysts of undetermined origin. EPO concentrations in cyst fluid obtained from proximal cysts were significantly higher than in fluid from cysts of undetermined origin (472.9 +/- 116.2 vs. 112.1 +/- 33.3 mU/ml, p < 0.05). Patients with proximal cysts had significantly higher plasma EPO levels (31.8 +/- 3.5 mU/ml) than healthy subjects (17.3 +/- 1.96 mU/ml, p < 0.005). We conclude that: (1) simple renal cysts of distal origin seem to be rare; (2) the presence of high EPO level in cyst fluid suggests its proximal origin; (3) estimation of cyst fluid EPO levels seems to be of similar pathogenetic value as the assessment of the cyst fluid/plasma sodium ratio.
据报道，常染色体显性多囊肾病（ADPKD）患者的囊肿液和血浆中促红细胞生成素（EPO）水平较高。在本研究中，我们评估了从50个单纯性肾囊肿获取的囊肿液的EPO水平及其生化组成。根据囊肿液/血浆钠比值，38个囊肿被归类为近端起源的囊肿，12个为起源不明的囊肿。从近端囊肿获取的囊肿液中的EPO浓度显著高于起源不明的囊肿液中的EPO浓度（472.9±116.2对112.1±33.3 mU/ml，p<0.05）。近端囊肿患者的血浆EPO水平（31.8±3.5 mU/ml）显著高于健康受试者（17.3±1.96 mU/ml，p<0.005）。我们得出结论：（1）远端起源的单纯性肾囊肿似乎很少见；（2）囊肿液中EPO水平高表明其近端起源；（3）估计囊肿液EPO水平似乎与评估囊肿液/血浆钠比值具有相似的致病价值。
