Jacobsson L, Lindqvist B, Michaelson G, Bjerle P
Acta Med Scand. 1977;202(4):327-9. doi: 10.1111/j.0954-6820.1977.tb16837.x.
Cystic puncture was performed percutaneously in 18 patients with solitary renal cysts and in 22 with multiple, congenital renal cysts. With the aid of tritiated water it was possible to estimate the fluid turnover in the cysts and compare it with their volume, pressure and potassium and creatinine levels. Fluid turnover was rapid in all the renal cysts. Two to five hours after i.v. injection of tritium, the tritium concentration in cystic fluid averaged 88% of the concentration in plasma fluid in patients with polycystic kidneys and 73 percent in patients with solitary cysts. Fluid turnover was more rapid in small than in large cysts, but there was no such difference between cysts with high and low pressure. It is possible that the fluid turnover was slightly faster in cysts with high potassium and creatinine levels than in those with low levels. The results show that the fluid turnover in a renal cyst of 10 ml is considerable--probably more than 100 ml/24 hours. This indicates that fluid inflow to the cyst comes mainly from cells in the cyst wall and not from a single glomerule. Fluid probably leaves the cyst actively via cells in the cyst wall, since the fluid turnover does not increase with high cyst pressure. The fluid turnover is probably secondary to the active solute transportation, which is performed by the cyst cells. This means that these cells have a tubular cell-like function and should respond to pharmacotherapy.
对18例孤立性肾囊肿患者和22例多发性先天性肾囊肿患者进行了经皮囊肿穿刺。借助氚标记水，可以估计囊肿内的液体周转率，并将其与囊肿的体积、压力以及钾和肌酐水平进行比较。所有肾囊肿的液体周转率都很快。静脉注射氚后2至5小时，多囊肾患者囊液中的氚浓度平均为血浆中氚浓度的88%，孤立性囊肿患者为73%。小囊肿的液体周转率比大囊肿快，但高压囊肿和低压囊肿之间没有这种差异。钾和肌酐水平高的囊肿的液体周转率可能比水平低的囊肿略快。结果表明，一个10毫升的肾囊肿中的液体周转率相当可观——可能超过100毫升/24小时。这表明进入囊肿的液体主要来自囊肿壁中的细胞，而不是单个肾小球。液体可能通过囊肿壁中的细胞主动离开囊肿，因为液体周转率不会随着囊肿高压而增加。液体周转率可能继发于囊肿细胞进行的主动溶质转运。这意味着这些细胞具有类似肾小管细胞的功能，应该对药物治疗有反应。
