Roth M P, Clayton J, Patois E, Alperovitch A
Centre de Recherche sur le Polymorphisme génétique des Populations humaines, CNRS UPR 8291, CHU Purpan, Toulouse, France.
Neuroepidemiology. 1994;13(5):211-5. doi: 10.1159/000110381.
The family histories of 7,802 multiple sclerosis (MS) patients were reviewed with respect to the familial pattern of the disease and the gender of the affected individuals. These patients joined an epidemiological study following a call for patients on French television and answered a questionnaire with the help of their physician. 170 had an affected parent, providing 72 mother-daughter pairs, 48 mother-son pairs, 37 father-daughter pairs, and 13 father-son pairs. From these data, the maximum likelihood estimate of the female to male ratio is 2.06, which is not different from what could be expected given the ratio of 2:1 usually found among patients. The apparent deficit of father-son concordant pairs probably simply reflects the well-known preponderance of the disease among females.
对7802例多发性硬化症（MS）患者的家族史进行了回顾，涉及疾病的家族模式以及受影响个体的性别。这些患者是在法国电视台呼吁患者后加入一项流行病学研究的，并在医生的帮助下回答了一份问卷。170例患者有患病的父母，其中有72对母女、48对母子、37对父女和13对父子。根据这些数据，女性与男性比例的最大似然估计值为2.06，这与通常在患者中发现的2:1的比例预期并无差异。父子一致对的明显不足可能仅仅反映了该疾病在女性中众所周知的优势。
