Sadovnick A D, Bulman D, Ebers G C
Department of Medical Genetics, University Hospital, University of British Columbia, Vancouver, Canada.
Ann Neurol. 1991 Mar;29(3):252-5. doi: 10.1002/ana.410290304.
It is now recognized that susceptibility to multiple sclerosis (MS) is determined in part by genetic factors. The gene loci influencing MS susceptibility are largely unidentified. In an attempt to better understand the mode of transmission, parent-child concordance for MS was studied in two large, population-based MS clinic populations. Among 75 parent-child pairs concordant for MS, we found 40 mother-daughter pairs, 13 mother-son pairs, 21 father-daughter pairs, and 1 father-son pair. Controlling for the known female preponderance in MS, the data show a paucity of father-son pairs. These data have implications for understanding the mechanisms of inheritance for MS susceptibility as well as for risk counseling in families of patients.
现在人们认识到，多发性硬化症（MS）的易感性部分由遗传因素决定。影响MS易感性的基因位点在很大程度上尚未明确。为了更好地理解其传播方式，我们在两个基于人群的大型MS临床人群中研究了MS的亲子一致性。在75对MS一致的亲子对中，我们发现有40对母女对、13对母子对、21对父女对和1对父子对。在控制了已知的MS女性优势后，数据显示父子对数量稀少。这些数据对于理解MS易感性的遗传机制以及为患者家庭提供风险咨询具有重要意义。
