Bjerregaard A, Jørgensen O S
Department of Pharmacology, Rigshospitalet, Copenhagen, Denmark.
Neurochem Res. 1994 Jul;19(7):789-93. doi: 10.1007/BF00967445.
The ontogeny of cell adhesion molecule L1 in cerebellum was quantitatively assessed in weaver and reeler mutant mice and in heterozygous litter-mate controls. In the latter the concentration and the amount of L1 both increased from the first postnatal week to become maximum at the second. In contrast, in the weaver and reeler neurologic mutant mice, L1 decreased steadily. The L1 concentration and the amount of L1 was lower in the cerebellum of homozygous mutant mice than in litter-mate controls. The findings are consistent with L1 being a component of axonal plasma membranes. However, no evidence was found of any direct effect of the wv and rl phenotypes on L1 expression.
在摇摆小鼠和旋转小鼠突变体以及杂合子同窝对照小鼠中，对小脑细胞粘附分子L1的个体发生进行了定量评估。在后者中，L1的浓度和含量从出生后的第一周开始都有所增加，并在第二周达到最大值。相比之下，在摇摆和旋转神经突变小鼠中，L1稳步下降。纯合突变小鼠小脑中L1的浓度和含量低于同窝对照。这些发现与L1是轴突质膜的一个组成部分是一致的。然而，没有发现wv和rl表型对L1表达有任何直接影响的证据。
