Piacentino R, Giobbe C, Giannotta M R, Porpiglia M, Minì D, Grio R
Istituto di Ginecologia e Ostetricia, Università degli studi di Torino.
Minerva Ginecol. 1994 Jul-Aug;46(7-8):413-6.
The use of gonadotropins in therapy has led to the appearance of a complication due to hyperstimulation, referred to as "syndrome due to ovarian hypertension" (SOH). There are three clinical stages of SOH: slight, moderate and severe, caused by a pathogenetic mechanism which is thought to involve the action of prostaglandins and the renin-angiotensin system leading to an alteration in capillary permeability with increased ovarian diameter. SOH can be prevented using a protocol to evaluate clinical conditions during therapy mainly based on hormone assays and echographic monitoring. SOH can be predicted but not prevented, thus making it important to commence immediate treatment for in-patients so as to restore the volume of blood and the blood protein load in the most severe cases.
促性腺激素在治疗中的使用导致了一种因过度刺激而出现的并发症，称为“卵巢高压综合征”（SOH）。SOH有三个临床阶段：轻度、中度和重度，其发病机制被认为涉及前列腺素和肾素-血管紧张素系统的作用，导致毛细血管通透性改变，卵巢直径增大。可以通过一个主要基于激素检测和超声监测来评估治疗期间临床状况的方案来预防SOH。SOH可以被预测但无法预防，因此对于住院患者立即开始治疗非常重要，以便在最严重的情况下恢复血容量和血液蛋白含量。
