Lin M T, Kao T Y, Su C F, Hsu S S
Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan, ROC.
Neurosci Lett. 1994 Jun 6;174(1):17-20. doi: 10.1016/0304-3940(94)90108-2.
During the onset of heat stroke, rabbits displayed hyperthermia (42.8 degrees C), decreased arterial blood pressure, increased intracranial pressure, decreased cerebral perfusion pressure and increased interleukin-1 beta production (in both the hypothalamus and plasma), compared to those of normothermic, control rabbits. In addition, the heat-stroke animals which received an i.v. injection of interleukin 1-receptor antagonist (200 micrograms/kg) had a survival time (interval between onset of heat stroke and death) longer than that of the heat-stroke animals which received control-vehicle solution. The data indicate that interleukin-1 production plays a role in pathogenesis of heat stroke in rabbits.
