Mailleux P, Preud'homme X, Albala N, Vanderwinden J M, Vanderhaeghen J J
Unité de Recherche sur le Cerveau, Faculté de Médecine, Université Libre de Bruxelles, Brussels, Belgium.
Neurosci Lett. 1994 Jul 4;175(1-2):25-7. doi: 10.1016/0304-3940(94)91069-3.
delta-9-Tetrahydrocannabinol (THC) is a major psychoactive component of cannabis. We here studied, by quantitative in situ hybridization at the macroscopic level, the possible modulatory effects of acute THC (5 mg/kg/i.p.) on gene expression of the growth factor pleiotrophin (PTN) in the adult rat forebrain. We found, 30 min after a single injection of THC, a significant increase of PTN mRNA concentrations in the cingulate cortex (38%), fronto-parietal cortex (31%) and caudate-putamen (27%). In conclusion, this is the first report on THC regulation of growth factor gene expression in the brain.
δ-9-四氢大麻酚（THC）是大麻的主要精神活性成分。我们在此通过宏观水平的定量原位杂交研究了急性注射THC（5毫克/千克/腹腔注射）对成年大鼠前脑生长因子多效蛋白（PTN）基因表达的可能调节作用。我们发现，单次注射THC后30分钟，扣带回皮质（增加38%）、额顶叶皮质（增加31%）和尾状核-壳核（增加27%）中的PTN mRNA浓度显著升高。总之，这是关于THC对大脑中生长因子基因表达调节作用的首次报道。
