载脂蛋白E的ε4等位基因增加中国人群患阿尔茨海默病的风险。
Epsilon 4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population.
作者信息
Hong C J, Liu T Y, Liu H C, Wang S J, Fuh J L, Chi C W, Lee K Y, Sim C B
机构信息
Neurological Institute, Veterans General Hospital-Taipei, Taiwan, Republic of China.
出版信息
Neurology. 1996 Jun;46(6):1749-51. doi: 10.1212/wnl.46.6.1749.
We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of epsilon 4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two epsilon 4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of epsilon 4 was also significant (chi 2 = 8.2, p = 0.004). Our results support the association between epsilon 4 and AD in the Chinese.
我们检测了56例晚发性散发性阿尔茨海默病（AD）中国患者及57名年龄相仿的中国对照者的载脂蛋白E基因型。AD组中ε4的频率显著高于对照组（23.2% 对7.9%，p = 0.003）。携带一个或两个ε4的个体患AD的优势比为2.96（95%可信区间1.11至8.03）。AD与ε4等位基因比例的线性趋势也具有显著性（χ2 = 8.2，p = 0.004）。我们的结果支持中国人群中ε4与AD之间的关联。
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