Cummiskey J M, McLaughlin H, Keelan P
Thorax. 1976 Dec;31(6):665-8. doi: 10.1136/thx.31.6.665.
Immunological abnormalities in sarcoidosis have been previously described. Cutaneous anergy to a wide variety of antigens first prompted the suggestion that the underlying defect may be of importance in the aetiology or pathogenesis of the disorder. The thymus derived lymphocytes appear to be particularly affected, and both quantitative and qualitative in vitro defects have been described in these cells in sarcoidosis patients. We have quantitatively investigated T and B cells in a series of 52 sarcoidosis patients, and our results indicate that, as a group, sarcoidosis patients have lower mean total lymphocyte counts and lower T cell counts than the control series in agreement and with other reports. We found no difference between B cells in the sarcoidosis and control groups. The quantitative abnormalities detected did not correlate with any of the clinical parameters which were investigated--stage of disease, duration of the disease, treatment regime, and activity of disease--and there was a considerable overlap between the results obtained in sarcoidosis patients and the controls. Our results indicate that these investigations are of little value in the management of sarcoidosis patients.
结节病的免疫异常此前已有描述。对多种抗原的皮肤无反应性首先提示潜在缺陷可能在该疾病的病因或发病机制中具有重要意义。胸腺来源的淋巴细胞似乎受到特别影响，并且在结节病患者的这些细胞中已描述了体外数量和质量方面的缺陷。我们对52例结节病患者的T细胞和B细胞进行了定量研究，我们的结果表明，作为一个群体，结节病患者的平均总淋巴细胞计数和T细胞计数低于对照组，这与其他报告一致。我们发现结节病组和对照组的B细胞之间没有差异。检测到的定量异常与所研究的任何临床参数均无相关性，这些临床参数包括疾病分期、病程、治疗方案和疾病活动度，并且结节病患者和对照组获得的结果有相当大的重叠。我们的结果表明，这些检查对结节病患者的管理价值不大。
