Capron J P, Payenneville H, Dumont M, Dupas J L, Lorriaux A
Lancet. 1978 Aug 12;2(8085):329-31.
A prospective, controlled study was carried out to determine if there was an association between hiatus hernia and cholelithiasis. The prevalence of gallstones was calculated in 100 patients (50 men and 50 women) with radiological evidence of hiatus hernia. 100 subjects (50 men and 50 women) without hiatus hernia, matched for age, body-weight, and number of pregnancies, acted as controls. Gallstones were twice as common in the former group (34%) as in the control group (17%) (P less than 0.01). Moreover, a comparison of the lipid composition of the gallbladder bile in 15 subjects operated on for hiatus hernia with that in 17 patients operated on for another digestive disease showed that the molar percentage of choelsterol in the bile and the cholesterol saturation index were significantly higher in the patients with hiatus hernia (9.3 +/- 1.1, mean +/- S.E.M., 1.41) than in the control subjects (5.9 +/- 0.5; 0.97) (P less than 0.01). These results suggest an association between hiatus hernia and cholelithiasis. It is likely that common factors, probably related to a low-residue diet, predispose to the two diseases.
开展了一项前瞻性对照研究，以确定食管裂孔疝与胆石症之间是否存在关联。计算了100例有食管裂孔疝放射学证据的患者（50名男性和50名女性）的胆结石患病率。100名无食管裂孔疝的受试者（50名男性和50名女性）作为对照，这些对照在年龄、体重和妊娠次数方面进行了匹配。胆结石在前一组（34%）中的发生率是对照组（17%）的两倍（P<0.01）。此外，对15例因食管裂孔疝接受手术的患者与17例因其他消化系统疾病接受手术的患者的胆囊胆汁脂质成分进行比较，结果显示，食管裂孔疝患者胆汁中胆固醇的摩尔百分比和胆固醇饱和指数（9.3±1.1，均值±标准误，1.41）显著高于对照组（5.9±0.5；0.97）（P<0.01）。这些结果表明食管裂孔疝与胆石症之间存在关联。可能存在一些共同因素，可能与低残渣饮食有关，易导致这两种疾病。
