Nawa Y, Ishikawa N, Tsuchiya K, Horii Y, Abe T, Khan A I, Itoh H, Ide H, Uchiyama F
Department of Parasitology, Miyiazaki Medical College, Japan.
Parasite Immunol. 1994 Jul;16(7):333-8. doi: 10.1111/j.1365-3024.1994.tb00358.x.
In the middle of the era of molecular biology, much less attention is paid to in vivo phenomena. However, carefully designed experimental systems in vivo still can provide valuable information as to the mechanisms underlying the establishment and maintenance of host-parasite relationships. In this review we describe the advantage of using concurrent infections with appropriately chosen combinations of different genera or different maturation stages of parasites to segregate the cellular responses of the host. By means of simple experimental approaches we have found that mucosal mast cells and goblet cells, both of which have long been considered as non-specific effectors, are in fact highly selective and specific effector cells of the host defence mechanisms capable of acting on the establishment and the expulsion of intestinal helminths.
在分子生物学时代中期，人们对体内现象的关注较少。然而，精心设计的体内实验系统仍能提供有关宿主 - 寄生虫关系建立和维持机制的有价值信息。在本综述中，我们描述了利用不同属或不同成熟阶段的寄生虫进行适当组合的同时感染来区分宿主细胞反应的优势。通过简单的实验方法，我们发现长期以来一直被视为非特异性效应细胞的黏膜肥大细胞和杯状细胞，实际上是宿主防御机制中高度选择性和特异性的效应细胞，能够作用于肠道蠕虫的建立和驱除。
