Chan M S, Medley G F, Jamison D, Bundy D A
WHO Collaborating Centre for the Epidemiology of Intestinal Parasitic Infections, Department of Biology, Imperial College, London, UK.
Parasitology. 1994 Sep;109 ( Pt 3):373-87. doi: 10.1017/s0031182000078410.
This paper presents a method of estimating the potential global morbidity due to human intestinal nematode infections (Ascaris lumbricoides, Trichuris trichiura and hookworms), based on the observed prevalence of infection. The method relies on the observed relationships between prevalence and intensity of infection, and between worm burden and potential morbidity. This approach is shown to be sensitive to the precision of the original prevalence estimates and, in particular, to the degree of spatial heterogeneity in levels of infection. The estimates presented here indicate that several tens of millions of children are likely to suffer developmental consequences from infection, and suggest that the global disease burden of geohelminthiasis may be significantly greater than was supposed.
本文基于观察到的感染率，提出了一种估算人类肠道线虫感染（蛔虫、鞭虫和钩虫）所致潜在全球发病率的方法。该方法依赖于观察到的感染率与感染强度之间的关系，以及蠕虫负荷与潜在发病率之间的关系。结果表明，这种方法对原始感染率估计的精度很敏感，尤其是对感染水平的空间异质性程度敏感。此处给出的估计表明，数千万儿童可能因感染而出现发育问题，并提示土源性蠕虫病的全球疾病负担可能比预想的要大得多。
