Kiba T, Tanaka K, Numata K, Hoshino M, Inoue S
Third Department of Internal Medicine, Yokohama City University, School of Medicine, Japan.
Pflugers Arch. 1994 Aug;428(1):26-9. doi: 10.1007/BF00374748.
Whether or not the hypothalamus is involved in initiating hepatic DNA synthesis after partial hepatectomy is unclear. To determine the role of the ventromedial hypothalamic nuclei in liver regeneration after partial hepatectomy, we studied hepatic DNA synthesis during liver regeneration in rats with bilateral lesions of these nuclei. Lesions of the ventromedial hypothalamus accelerated the increase in hepatic DNA synthesis and raised the peak level of thymidine incorporation after partial hepatectomy. These effects of hypothalamic lesions were completely inhibited by hepatic vagotomy. Thus, lesions of the ventromedial hypothalamus appear to promote hepatic regeneration by increasing vagal stimulation of the liver.
下丘脑是否参与部分肝切除术后启动肝脏DNA合成尚不清楚。为了确定腹内侧下丘脑核在部分肝切除术后肝脏再生中的作用，我们研究了这些核双侧损伤的大鼠肝脏再生过程中的肝脏DNA合成。腹内侧下丘脑损伤加速了肝脏DNA合成的增加，并提高了部分肝切除术后胸苷掺入的峰值水平。肝脏迷走神经切断术完全抑制了下丘脑损伤的这些作用。因此，腹内侧下丘脑损伤似乎通过增加迷走神经对肝脏的刺激来促进肝脏再生。
