Potron G, Jolly D, Nguyên P, Mailliot J L, Pignon B
Laboratoire Central d'Hématologie, Centre Hospitalier Régional et Universitaire, Hôpital Robert Debré, Reims, France.
Nouv Rev Fr Hematol (1978). 1994 Jun;36(3):241-7.
Erythrocyte sedimentation rate (ESR) is mainly used in clinical practice as a screening test for inflammatory diseases and sometimes in the follow-up of patients. However, ESR is highly dependent on erythrocyte aggregation. In this study, using a Sediscan (Becton) automatic device measuring the kinetics of ESR, these results are compared with the measurement of erythrocyte aggregation as determined by laser light backscattering (Erythroaggregometer Affibio). A series of 188 samples from in-patients were tested. Statistical analysis of 13 parameters indicates that 82% of ESR variance may be explained by fibrinogen level, haematocrit and a parameter characterizing erythrocyte aggregation: the aggregation index at 10 s. This correlation was then validated prospectively in 128 other patients and seems to be independent of the underlying disease. Thus ESR in combination with fibrinogen assay and haematocrit may be considered as a simple and economic method to assess erythrocyte aggregation.
红细胞沉降率（ESR）在临床实践中主要用作炎症性疾病的筛查试验，有时也用于患者的随访。然而，ESR高度依赖于红细胞聚集。在本研究中，使用Sediscan（贝克顿）自动装置测量ESR的动力学，并将这些结果与通过激光背散射测定的红细胞聚集（红细胞聚集仪Affibio）测量结果进行比较。对188份住院患者样本进行了检测。对13个参数的统计分析表明，ESR方差的82%可由纤维蛋白原水平、血细胞比容以及一个表征红细胞聚集的参数：10秒时的聚集指数来解释。然后在另外128名患者中对这种相关性进行了前瞻性验证，并且似乎与基础疾病无关。因此，ESR与纤维蛋白原测定和血细胞比容相结合可被视为一种评估红细胞聚集的简单且经济的方法。
