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六例巴氯芬中毒——临床病程及传统治疗与血液透析评估

[Six cases of baclofen poisoning--clinical course and evaluation of conventional treatment and hemodialysis].

作者信息

Kozak G

机构信息

III Oddziału Chorób Wewnetrznych Szpitala Praskiego i Stołecznego Ośrodka Ostrych Zatruć.

出版信息

Pol Arch Med Wewn. 1994 Jul;92(1):63-9.

PMID:7971479
Abstract

6 cases of baclofen overdose were presented. Intentional (suicidal) poisonings of baclofen are rare but their course is serious because of deep coma and cardiodepression. Till now the baclofen poisonings have been treated conventionally. Basing on the pharmacological data (action and kinetics) of baclofen and high severity of poisoning haemodialysis was used in all of them with good effect. The efficacy of such treatment was evaluated and results were compared to the toxicological literature data.

摘要

本文报告了6例巴氯芬过量病例。巴氯芬的故意(自杀性)中毒很少见,但由于深度昏迷和心脏抑制,其病程严重。到目前为止,巴氯芬中毒一直采用传统方法治疗。根据巴氯芬的药理学数据(作用和动力学)以及中毒的高度严重性,对所有患者均采用了血液透析,效果良好。评估了这种治疗方法的疗效,并将结果与毒理学文献数据进行了比较。

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