Kalinin A P, Rafibekov D S, Potemkina E E, Shabadin V N
Probl Endokrinol (Mosk). 1994 Jul-Aug;40(4):21-3.
T-cellular immunity was studied in 104 patients with autoimmune thyroiditis to assess the function of the thyroid and treatment method. A reliable reduction of the activity of T-lymphocyte receptor system, lymphopoiesis activation, and their relationship with the thyroid status were revealed. Plasmapheresis as monotherapy was used in 22 patients. It brought about a short-term positive effect, this necessitating search for other methods of immuno-rehabilitation. In 82 patients it was supplemented with immunocorrective therapy (thymalin) and in 49 with hypothyrosis with substitution therapy (L-thyroxine, thyroidin). Combined therapy helped attain a stable clinical and immunological effect. Subpopulation composition of T-lymphocytes recovered, their functional activity normalized (follow-up period 1 year).
对104例自身免疫性甲状腺炎患者的T细胞免疫进行了研究，以评估甲状腺功能及治疗方法。结果发现T淋巴细胞受体系统活性、淋巴细胞生成激活以及它们与甲状腺状态之间存在可靠的降低关系。22例患者采用血浆置换作为单一疗法。该疗法产生了短期积极效果，因此有必要寻找其他免疫康复方法。82例患者补充了免疫纠正疗法（胸腺素），49例患者补充了甲状腺功能减退替代疗法（左旋甲状腺素、甲状腺素）。联合治疗有助于获得稳定的临床和免疫效果。T淋巴细胞亚群组成恢复，其功能活性正常化（随访期1年）。
