Artemova E P, Nugmanova L B
Probl Endokrinol (Mosk). 1991 Sep-Oct;37(5):44-7.
The purpose of this experiment was to investigate the suppression of autoimmune thyroiditis in guinea-pigs by prolonged stimulation of T-cellular immunity with T-activin, a thymic hormone. The development of experimental autoimmune thyroiditis (EAT) at early stages was shown to be characterized by deficiency of T-cells of helper and suppressor phenotypes, hypersecretion of thyroid hormones and insignificant development of a thyroid autoimmune process. With disease development indices of peripheral blood immunity of guinea-pigs were close to normal, and the frequency and degree of lymphoid infiltration of the gland were increased in parallel with the development of hypofunction of the organ. Immuno-correction of developing EAT with injections of T-activin according to our scheme resulted in a prolonged stimulation of T-cellular immunity, prevented sensitization of lymphocytes with thyroid antigens, increased secretion of the thymic hormones in parallel with a decrease in a degree of lymphoid-plasmacytic infiltration from thyroid tissues, indicating suppression of the disease.
本实验的目的是研究用胸腺激素T-激活素长期刺激T细胞免疫对豚鼠自身免疫性甲状腺炎的抑制作用。实验性自身免疫性甲状腺炎（EAT）早期发展的特征是辅助性和抑制性表型的T细胞缺乏、甲状腺激素分泌过多以及甲状腺自身免疫过程发展不明显。随着疾病的发展，豚鼠外周血免疫指标接近正常，腺体淋巴浸润的频率和程度随着器官功能减退的发展而平行增加。按照我们的方案用T-激活素注射对正在发展的EAT进行免疫纠正，可导致T细胞免疫的长期刺激，防止淋巴细胞对甲状腺抗原的致敏，增加胸腺激素的分泌，同时甲状腺组织中淋巴-浆细胞浸润程度降低，表明疾病得到抑制。
