Vykhodtseva N I, Gavrilov L R, Mering T A, Iamshchikova N G
Zh Nevropatol Psikhiatr Im S S Korsakova. 1976 Dec;76(12):1810-6.
It was demonstrated that destruction of the brain can be accomplished by different combinations of ultrasound intensity and duration of irradiation. By experimental means cavitational thresholds of brain tissues were determined and a calculation was made of increased temperature in the zone of focus in each separate regime of irradiation. The authors describe the foci of lesions where the main mechanism of destruction was only warmth, either only cavitation, either warmth and cavitation together. Irradiation of deep brain structures was not accompanied by changes of the cortical and subcortical structures, located above the focus of necrosis along the path of the ultrasound ray (light microscopy). The probability of a target hit into the given brain structure corresponded to the preciseness allowed in a stereotaxic operation.
结果表明,通过超声强度和照射持续时间的不同组合可以实现对大脑的破坏。通过实验手段确定了脑组织的空化阈值,并对每种单独照射方案下焦点区域的温度升高进行了计算。作者描述了病变焦点,其中破坏的主要机制要么仅是热,要么仅是空化,要么是热和空化共同作用。对深部脑结构的照射并未伴随沿超声束路径位于坏死焦点上方的皮质和皮质下结构的变化(光学显微镜检查)。命中给定脑结构的概率与立体定向手术中允许的精确性相当。