Vogl T J, Hoffmann Y, Mühler A, Felix R
Strahlenklinik und Poliklinik, Universitätsklinikum Rudolph Virchow, Freien Universität Berlin, Standort Wedding.
Radiologe. 1994 Aug;34(8):423-9.
Magnetic resonance angiography (MRA) protocols are based on standard sequence protocols like time of flight MRA, which evaluates inflowing spins. This technique is limited by a variety of artifacts like the saturation artifact via turbulent blood flow. Contrast media diminish these artifacts like extracellular agents and blood-pool contrast media. The clinical value of the contrast-enhanced MRA for cerebral pathologies is based on the use of the paramagnetic contrast agent Gd-DTPA. For extracerebral diseases this technique is restricted because of the simultaneous visualization of both arterial and venous vascular territories. Occult venous sinus thrombosis or AV malformations are clinical essential indications for the use of C-MRA. Experimental data prove the excellent contrast abilities of blood-pool agents like Gd-DTPA-polylysin or Gd-DTPA-albumin, which demonstrate long intravascular persistence and retarded excretion.
磁共振血管造影（MRA）协议基于标准序列协议，如评估流入自旋的飞行时间MRA。该技术受到多种伪影的限制，如湍流血液流动导致的饱和伪影。造影剂可减少这些伪影，如细胞外剂和血池造影剂。对比增强MRA对脑部病变的临床价值基于顺磁性造影剂钆喷酸葡胺（Gd-DTPA）的使用。对于脑外疾病，由于同时显示动脉和静脉血管区域，该技术受到限制。隐匿性静脉窦血栓形成或动静脉畸形是使用对比增强MRA的临床重要指征。实验数据证明了血池剂如钆喷酸葡胺-聚赖氨酸（Gd-DTPA-聚赖氨酸）或钆喷酸葡胺-白蛋白的优异对比能力，它们显示出长时间的血管内滞留和排泄延迟。
