Yano T, Kodama T, Suzuki Y, Watanabe K
Department of Radiology, Miyazaki Medical College, Japan.
Acta Radiol. 1997 Jan;38(1):47-54. doi: 10.1080/02841859709171241.
To evaluate the influences of Gd-DTPA on 3D time-of-flight (TOF) MR angiography (MRA).
In an experimental study using a flow phantom, contrast 3D TOF MRA was performed at varying Gd-DTPA concentrations, flow rates, TRs and flip angles. In a clinical study, cranial 3D TOF MR angiograms using Gd-DTPA were obtained in 38 patients to evaluate the efficacy of Gd-DTPA in enhancing the diagnosis of intracranial vascular lesions. Visualization of the venous system and distal arterial branches on contrast MRA was compared with those of noncontrast MRA.
In the experimental study, progressive signal loss of inflowing spins due to saturation was smaller with higher concentration of Gd-DTPA. The influences of Gd-DTPA on the saturation effect were more pronounced with a slower flow rate, shorter TR and larger flip angles. In the clinical study, i.v. administration of Gd-DTPA improved the visualization of the venous system and distal arterial branches on 3D TOF MRA. The diagnostic value of MRA was enhanced by Gd-DTPA in patients with intracranial vascular lesions such as vascular malformations and large aneurysms.
The T1-shortening effect of Gd-DTPA reduced the signal loss of vessels with slow flow rate, and contrast MRA was particularly useful for evaluation of venous abnormalities. Compared with conventional MRA, shorter TRs and larger flip angles were considered beneficial in contrast MRA.
评估钆喷酸葡胺（Gd-DTPA）对三维时间飞跃法（TOF）磁共振血管造影（MRA）的影响。
在一项使用流动模型的实验研究中，在不同的Gd-DTPA浓度、流速、重复时间（TR）和翻转角条件下进行对比三维TOF MRA。在一项临床研究中，对38例患者进行了使用Gd-DTPA的头颅三维TOF磁共振血管造影，以评估Gd-DTPA在增强颅内血管病变诊断方面的疗效。将对比MRA上静脉系统和远端动脉分支的显影情况与非对比MRA的情况进行比较。
在实验研究中，随着Gd-DTPA浓度升高，流入自旋因饱和导致的信号逐渐丢失较少。Gd-DTPA对饱和效应的影响在流速较慢、TR较短和翻转角较大时更为明显。在临床研究中，静脉注射Gd-DTPA改善了三维TOF MRA上静脉系统和远端动脉分支的显影。对于患有颅内血管病变如血管畸形和大型动脉瘤的患者，Gd-DTPA增强了MRA的诊断价值。
Gd-DTPA的T1缩短效应减少了流速缓慢血管的信号丢失，对比MRA对评估静脉异常特别有用。与传统MRA相比，较短的TR和较大的翻转角在对比MRA中被认为是有益的。
