Bellin M F, Zaim S, Auberton E, Sarfati G, Duron J J, Khayat D, Grellet J
Department of Radiology, Hôpital Pitié-Salpétrière, Paris, France.
Radiology. 1994 Dec;193(3):657-63. doi: 10.1148/radiology.193.3.7972804.
To evaluate the clinical and biologic safety of superparamagnetic iron oxide (SPIO) as a contrast agent in magnetic resonance (MR) imaging and to assess its efficacy in the detection of liver metastases.
Twenty adults with liver metastases underwent MR imaging at 1.5 T before and 1 hour after infusion of SPIO. Four spin-echo (SE) sequences and one gradient-echo (GRE) sequence were used.
There were no adverse reactions. Alterations in serum protein, serum iron, transferrin, and ferritin levels and transferrin saturation coefficient were statistically significant. The mean tumor-to-liver contrast-to-noise ratio (C/N) increased markedly with all sequences. The best postcontrast tumor-to-liver contrast was obtained with the GRE sequence (repetition time msec/echo time msec = 300/15). The mean number of apparent lesions detected after administration of SPIO increased by 12 with the proton-density-weighted SE sequences (800/30 and 2,500/30), four with the T2-weighted SE sequence (2,500/90), and seven with the GRE sequence (300/15).
SPIO is safe, increases tumor-to-liver C/Ns with some sequences, and improves the detection of liver metastases.
评估超顺磁性氧化铁（SPIO）作为磁共振（MR）成像造影剂的临床和生物安全性，并评估其在检测肝转移瘤方面的有效性。
20例患有肝转移瘤的成年人在输注SPIO前及输注后1小时接受了1.5T的MR成像检查。使用了四个自旋回波（SE）序列和一个梯度回波（GRE）序列。
未出现不良反应。血清蛋白、血清铁、转铁蛋白、铁蛋白水平及转铁蛋白饱和系数的变化具有统计学意义。所有序列的平均肿瘤与肝脏对比噪声比（C/N）均显著增加。使用GRE序列（重复时间毫秒/回波时间毫秒 = 300/15）获得了最佳的造影后肿瘤与肝脏对比度。在使用质子密度加权SE序列（800/30和2500/30）后，注射SPIO后检测到的平均明显病变数量增加了12个，使用T2加权SE序列（2500/90）后增加了4个，使用GRE序列（300/15）后增加了7个。
SPIO是安全的，某些序列可提高肿瘤与肝脏的C/N，改善肝转移瘤的检测。
