Namkung Sook, Zech Christoph J, Helmberger Thomas, Reiser Maximilian F, Schoenberg Stefan O
Institute of Clinical Radiology, Munich University Hospitals-Grosshadern, Munich, Germany.
J Magn Reson Imaging. 2007 Apr;25(4):755-65. doi: 10.1002/jmri.20873.
To evaluate the efficacy of ferucarbotran in T2-weighted (T2W) fast spin-echo (FSE) and T2*W gradient-echo (GRE) sequences for characterizing focal liver lesions.
In 68 patients, 46 malignant and 22 benign focal liver lesions were evaluated. Precontrast (NCE) T2W FSE images and contrast-enhanced (CE) T2W FSE and T2W GRE images were obtained on a 1.5T MR system. Based on signal intensity (SI) measurements in focal lesions and liver parenchyma, the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated for all sequences. The percentage of SI loss (PSIL) in focal lesions after contrast agent (CA) application was calculated for the T2W FSE sequence. Qualitative analyses were performed to assess image quality and lesion conspicuity obtained with the CE-T2W FSE and CE-T2W GRE sequences.
The mean PSIL was higher in solid benign lesions than in malignant lesions (39.6% vs. 3.2%, P<0.05). With a threshold PSIL of 25%, the sensitivity and specificity for characterizing malignant lesions were 97.8% and 92.9%, respectively. The mean CNR of the malignant lesions was higher in the CE-T2W sequence than in the CE- and NCE-T2W FSE sequences (29.9 vs. 22.7 (P<0.01) vs. 12.8 (P<0.01)). CE-T2W images showed a superior image quality and lesion conspicuity (P<0.05) compared to the CE-T2W FSE sequence.
The PSIL can be an accurate tool for characterizing benign and malignant lesions. The addition of a CE-T2*W GRE sequence is helpful for the detection and characterization of malignant lesions.
评估 ferucarbotran 在 T2 加权（T2W）快速自旋回波（FSE）和 T2*加权梯度回波（GRE）序列中对肝脏局灶性病变进行特征性诊断的效能。
对 68 例患者的 46 个恶性和 22 个良性肝脏局灶性病变进行评估。在 1.5T MR 系统上获取对比剂前（NCE）T2W FSE 图像以及对比增强（CE）T2W FSE 和 T2W GRE 图像。根据局灶性病变和肝实质的信号强度（SI）测量值，计算所有序列的信噪比（SNR）和对比噪声比（CNR）。对于 T2W FSE 序列，计算对比剂（CA）注射后局灶性病变中 SI 损失百分比（PSIL）。进行定性分析以评估 CE-T2W FSE 和 CE-T2W GRE 序列获得的图像质量和病变清晰度。
实性良性病变的平均 PSIL 高于恶性病变（39.6%对 3.2%，P<0.05）。以 25%的 PSIL 阈值来鉴别恶性病变时，敏感性和特异性分别为 97.8%和 92.9%。恶性病变的平均 CNR 在 CE-T2W 序列中高于 CE-和 NCE-T2W FSE 序列（分别为 29.9 对 22.7（P<0.01）对 12.8（P<0.01））。与 CE-T2W FSE 序列相比，CE-T2W 图像显示出更好的图像质量和病变清晰度（P<0.05）。
PSIL 可作为鉴别良性和恶性病变的准确工具。添加 CE-T2*W GRE 序列有助于恶性病变的检测和特征性诊断。
