Riutta A, Kerttula T, Sievi E, Alanko J
Department of Biomedical Sciences, University of Tampere, Finland.
Prostaglandins. 1994 Jul;48(1):43-51. doi: 10.1016/0090-6980(94)90095-7.
We have previously shown that adrenaline infusion induces an almost twofold increase in systemic thromboxane synthesis, measured as urinary 11-dehydrothromboxane B2. The purpose of the present study was to investigate whether high levels of adrenaline, found e.g. in heavy physical exercise and myocardial infarction are involved in the regulation of prostacyclin synthesis. To this end the effect of adrenaline infusion (0.1 microgram/kg/min for 45 min and thereafter 0.2 microgram/kg/min for 15 min) on prostacyclin synthesis in healthy male volunteers was investigated. Adrenaline infusion produced an over twofold increase in systemic prostacyclin synthesis, measured as urinary 2,3-dinor-6-keto-prostaglandin F1 alpha. Our study demonstrates that high circulating levels of adrenaline are associated with increased formation of prostacyclin.
我们之前已经表明，以尿11-脱氢血栓素B2为指标，输注肾上腺素会使全身血栓素合成增加近两倍。本研究的目的是调查在例如剧烈体育锻炼和心肌梗死中发现的高水平肾上腺素是否参与前列环素合成的调节。为此，研究了在健康男性志愿者中输注肾上腺素（0.1微克/千克/分钟，持续45分钟，之后0.2微克/千克/分钟，持续15分钟）对前列环素合成的影响。以尿2,3-二去甲-6-酮-前列腺素F1α为指标，输注肾上腺素使全身前列环素合成增加了两倍多。我们的研究表明，高循环水平的肾上腺素与前列环素形成增加有关。
